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PMVK Monoclonal Antibody [PAT21C10AT] (CPAB0198)

SKU:
CPAB0198
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PAT21C10AT
Applications:
WB
ELISA
FC
€149
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Description

system_update_alt Datasheet

PMVK Monoclonal Antibody [PAT21C10AT] (CPAB0198)

The PMVK Polyclonal Antibody (CPAB0198) is a valuable tool for researchers studying the enzyme PMVK, which is involved in the mevalonate pathway and plays a crucial role in cholesterol biosynthesis. This antibody, raised in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the PMVK protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies focusing on lipid metabolism, cholesterol regulation, and related pathways.PMVK is a key enzyme in the mevalonate pathway, which is essential for the production of isoprenoid compounds that are involved in various cellular processes, including cell growth, proliferation, and signaling.

Dysregulation of this pathway has been linked to diseases such as hypercholesterolemia, cardiovascular diseases, and certain cancers. By investigating the role of PMVK in these conditions, researchers can gain important insights into potential therapeutic strategies targeting cholesterol metabolism and related pathways.Overall, the PMVK Polyclonal Antibody (CPAB0198) provides a valuable tool for researchers interested in studying the mevalonate pathway, cholesterol biosynthesis, and related processes. Its high reactivity, specificity, and reliability make it a valuable asset for research in the fields of biochemistry, molecular biology, and lipid metabolism.

Product Name:PMVK Antibody
Product Sku:CPAB0198
Size:5μg
Host Species:Mouse
Immunogen:Anti-human PMVK mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PMVK amino acids 1-192 purified from Ecoli.
Clone:PAT21C10AT.
Reactivity:Human
Applications:Western Blot, ELISA, Flow Cytometry
Purification Method:PMVK antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2a
Background:Phosphomevalonate kinase (PMVK) is a cytosolic enzyme. PMVK is expressed highly in the heart, liver, skeletal muscle, kidney and pancreas and slightly lower in the brain, placenta, and lung. PMVK catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate in the fifth reaction of the cholesterol biosynthetic pathway. Induced by sterol, PMVK participates in isopentenyl diphosphate biosynthesis via the mevalonate pathway.
Synonyms:Phosphomevalonate kinase, PMKase, hPMK, PMVK, PMKI, PMK, PMKA, PMKASE, HUMPMKI.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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