The PMS2 Polyclonal Antibody (PACO4625) is a cutting-edge tool for researchers studying the PMS2 protein, a key player in DNA mismatch repair. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been rigorously validated for use in Western blotting applications. By binding specifically to the PMS2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an indispensable resource for studies in genetics and cancer research.PMS2 is a critical component of the DNA mismatch repair system, responsible for identifying and correcting errors in DNA replication.
Mutations in the PMS2 gene have been linked to Lynch syndrome, a hereditary cancer predisposition syndrome. Research into the function of PMS2 is essential for understanding the mechanisms of tumorigenesis and developing targeted therapies for cancer treatment. By elucidating the role of PMS2 in maintaining genomic stability, researchers can pave the way for advancements in personalized medicine and precision oncology.
Antibody Name:
PMS2CL/PMS2 Antibody
Antibody SKU:
PACO04625
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the C-terminal region of human PMS2/PMS2CL.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
PMS2CL; Protein PMS2CL; PMS2-C terminal-like protein; PMS2; PMSL2; Mismatch repair endonuclease PMS2; DNA mismatch repair protein PMS2; PMS1 protein homolog 2
UniProt Protein Function:
CautionAccording to PubMed:15077197, it is a pseudogene. However, a peptide specific to this protein was identified by mass spectrometry (PubMed:17525332). Given that the product described by PubMed:15077197 is located downstream and on another frame of the transcript, it may explain why PubMed:15256438 could not detect this protein on a Western blot.
