The PMS2 Polyclonal Antibody (CAB6947) is a powerful tool for research involving the PMS2 protein, a key player in DNA mismatch repair. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the PMS2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for studying DNA repair mechanisms and genetic diseases.PMS2 is a crucial component of the DNA mismatch repair system, which plays a critical role in maintaining genomic stability and preventing the accumulation of mutations that can lead to cancer and other diseases.
Understanding the function of PMS2 is essential for unraveling the molecular mechanisms underlying genetic disorders and developing targeted therapies for cancer and other conditions related to DNA damage. With its high specificity and reliability, the PMS2 Polyclonal Antibody is an invaluable resource for researchers working in the fields of genetics, oncology, and molecular biology.
Product Name:
PMS2 Rabbit Polyclonal Antibody
SKU:
CAB6947
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PMS2 (NP_000526.2).
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.
Purification Method:
Affinity purification
Gene ID:
5395
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PMS2 Rabbit pAb (CAB6947) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
