PMS2 Rabbit Polyclonal Antibody (CAB13680)
- SKU:
- CAB13680
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | PMS2 Rabbit Polyclonal Antibody |
SKU: | CAB13680 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 390-670 of human PMS2 (NP_000526.2). |
Sequence: | ADLE KPMV EKQD QSPS LRTG EEKK DVSI SRLR EAFS LRHT TENK PHSP KTPE PRRS PLGQ KRGM LSSS TSGA ISDK GVLR PQKE AVSS SHGP SDPT DRAE VEKD SGHG STSV DSEG FSIP DTGS HCSS EYAA SSPG DRGS QEHV DSQE KAPK TDDS FSDV DCHS NQED TGCK FRVL PQPT NLAT PNTK RFKK EEIL SSSD ICQK LVNT QDMS ASQV DVAV KINK KVVP LDFS MSSL AKRI KQLH HEAQ QSEG EQNY RKFR AKIC PGEN QAAE DELR KEIS K |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | MLH4; PMS-2; PMSL2; HNPCC4; LYNCH4; MMRCS4; PMS2CL; S2 |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 96kDa |
Observed MW: | 110kDa |
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.
Purification Method: | Affinity purification |
Gene ID: | 5395 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |