The PMS1 Polyclonal Antibody (CAB2183) is a valuable tool for researchers studying the PMS1 protein, a key player in DNA mismatch repair processes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the PMS1 protein, this antibody allows for the detection and analysis of PMS1 in a variety of cell types, making it well-suited for studies in genetics, cancer research, and other fields where DNA repair mechanisms are of interest.PMS1 is essential for maintaining the integrity of the genome by correcting errors that occur during DNA replication, making it a critical factor in preventing mutations that can lead to cancer and other diseases.
Research into the function and regulation of PMS1 is vital for understanding how DNA repair mechanisms contribute to overall cellular health and for developing targeted therapies to treat conditions related to genome instability. The PMS1 Polyclonal Antibody provides a powerful tool for investigating the role of PMS1 in these processes.
Product Name:
PMS1 Rabbit Polyclonal Antibody
SKU:
CAB2183
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 405-619 of human PMS1 (NP_000525.1).
This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome.
Purification Method:
Affinity purification
Gene ID:
5378
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PMS1 Rabbit pAb (CAB2183) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
