The PMS1 Polyclonal Antibody (CAB14046) is a valuable tool for researchers studying PMS1, a protein involved in DNA mismatch repair. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the PMS1 protein, this antibody allows for the detection and analysis of PMS1 expression in a variety of cell types, making it ideal for studies in genetics and cancer research.PMS1 is a key player in maintaining genomic stability by correcting errors that occur during DNA replication.
Mutations in the PMS1 gene have been linked to an increased risk of cancer, making it an important target for research in oncology. Understanding the function of PMS1 and its role in DNA repair processes is essential for advancing our knowledge of cancer development and potentially identifying new therapeutic targets. The PMS1 Polyclonal Antibody will enable researchers to further explore the impact of PMS1 dysregulation in disease states and contribute to the development of innovative treatment strategies.
Product Name:
PMS1 Rabbit Polyclonal Antibody
SKU:
CAB14046
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 405-619 of human PMS1 (NP_000525.1).
This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome.
Purification Method:
Affinity purification
Gene ID:
5378
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PMS1 antibody (CAB14046) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
