The PMRT15 Polyclonal Antibody (PAC057308) is a crucial tool for research involving PMRT15, a protein associated with mitochondrial functions and energy metabolism. This antibody, generated in rabbits, boasts high reactivity with human samples and is validated for use in Western blot applications. By binding to the PMRT15 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an invaluable asset for studies in mitochondrial biology and metabolic disorders.PMRT15, also known as a key regulator of mitochondrial function, plays a pivotal role in maintaining cellular energy production and metabolic homeostasis.
Its involvement in mitochondrial processes makes it a promising target for investigations into diseases like metabolic syndromes, neurodegenerative disorders, and cancer. Deepening our understanding of PMRT15 is essential for advancing research efforts aimed at developing therapeutic interventions that target mitochondrial dysfunction in these pathological contexts.
Antibody Name:
PMRT15 Antibody (PACO57308)
Antibody SKU:
PACO57308
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Arabidopsis thaliana
Immunogen:
Recombinant Arabidopsis thaliana Protein arginine N-methyltransferase 1.5 protein (513-637AA)
Western Blot. Positive WB detected in Recombinant protein. All lanes: PMRT15 antibody at 5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 44 kDa. Observed band size: 44 kDa.
Background:
Methylates arginine residues of myelin basic protein (MBP) in vitro. Methylates symmetrically histone H4 of the FLC chromatin to form H4R3me2s, which in turn suppresses FLC expression to induce flowering. Regulates alternative splicing by methylating spliceosomal proteins. Involved in the post-transcriptional regulation of the circadian clock.
Synonyms:
Protein arginine N-methyltransferase 1.5 (AtPMRT15) (AtPMRT5) (EC 2.1.1.319) (Shk1 kinase-binding protein 1 homolog), PMRT15, PMRT5 SKB1
UniProt Protein Function:
Methylates arginine residues of myelin basic protein (MBP) in vitro. Methylates symmetrically histone H4 of the FLC chromatin to form H4R3me2s, which in turn suppresses FLC expression to induce flowering. Regulates alternative splicing by methylating spliceosomal proteins. Involved in the post-transcriptional regulation of the circadian clock.
UniProt Protein Details:
NCBI Summary:
Involved in vernalization. Required for epigenetic silencing of FLC, and for vernalization-mediated histone modification.
