The PMM2 Polyclonal Antibody (CAB4026) is a valuable tool for researchers studying PMM2, a key enzyme involved in protein glycosylation. This antibody, produced in rabbits, shows high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to the PMM2 protein, this antibody allows for the detection and analysis of PMM2 levels in various cell types.PMM2, also known as phosphomannomutase 2, plays a vital role in the biosynthesis of complex glycoproteins, making it essential for proper cellular function. Dysregulation of PMM2 has been linked to a range of disorders, including congenital disorders of glycosylation and neurological conditions.
Research into the function and regulation of PMM2 is crucial for understanding these diseases and developing potential therapies.With its specificity and reliability in detecting PMM2, the CAB4026 antibody is an invaluable tool for investigations into the role of PMM2 in health and disease. Whether studying glycosylation pathways, genetic disorders, or potential therapeutic targets, this antibody provides researchers with a reliable means to explore the intricacies of PMM2 biology.
Product Name:
PMM2 Rabbit Polyclonal Antibody
SKU:
CAB4026
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-246 of human PMM2 (NP_000294.1).
The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I.
Purification Method:
Affinity purification
Gene ID:
5373
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PMM2 antibody (CAB4026) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
