PMM1 Antibody (PACO29022)
- SKU:
- PACO29022
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PMM1 Antibody (PACO29022)
The PMM1 Polyclonal Antibody (PAC029022) is a valuable tool for researchers studying PMM1, a key enzyme involved in the biosynthesis of N-glycans. This antibody is produced in rabbits and is highly specific to human samples, making it an excellent choice for Western blot experiments. By binding to the PMM1 protein, this antibody allows for the detection and analysis of PMM1 in various cell types, making it an essential tool for studies in glycobiology and metabolic disorders.PMM1 plays a crucial role in the glycosylation process, which is essential for normal cellular function.
Dysregulation of PMM1 has been linked to various diseases, including congenital disorders of glycosylation and cancer. Understanding the function of PMM1 is essential for developing targeted therapies for these conditions. With its high specificity and reliability, the PMM1 Polyclonal Antibody is a valuable asset for researchers aiming to unravel the complex roles of PMM1 in health and disease.
| Antibody Name: | PMM1 Antibody (PACO29022) |
| Antibody SKU: | PACO29022 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Phosphomannomutase 1 protein (2-262AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: PMM1 antibody at 2µg/ml Lane 1: HepG2 whole cell lysate Lane 2: NIH/3T3 whole cell lysate Lane 3: 293T whole cell lysate Lane 4: Mouse brain tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 30 kDa Observed band size: 30 kDa . |
 | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO29022 at dilution of 1:100. |
| Background: | Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. |
| Synonyms: | Phosphomannomutase 1 (PMM 1) (EC 5.4.2.8) (PMMH-22), PMM1, PMMH22 |
| UniProt Protein Function: | PMM1: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. Belongs to the eukaryotic PMM family.Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; EC 5.4.2.8; IsomeraseChromosomal Location of Human Ortholog: 22q13.2Cellular Component: cytosolMolecular Function: phosphomannomutase activity; protein bindingBiological Process: GDP-mannose biosynthetic process; mannose metabolic process; protein amino acid N-linked glycosylation; protein targeting to ER |
| UniProt Protein Details: | |
| NCBI Summary: | Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92871 |
| NCBI GenInfo Identifier: | 194097356 |
| NCBI Gene ID: | 5372 |
| NCBI Accession: | NP_002667.2 |
| UniProt Secondary Accession: | Q92871,Q92586, A8K003 |
| UniProt Related Accession: | Q92871 |
| Molecular Weight: | 29,747 Da |
| NCBI Full Name: | phosphomannomutase 1 |
| NCBI Synonym Full Names: | phosphomannomutase 1 |
| NCBI Official Symbol: | PMM1Â Â |
| NCBI Official Synonym Symbols: | Sec53Â Â |
| NCBI Protein Information: | phosphomannomutase 1 |
| UniProt Protein Name: | Phosphomannomutase 1 |
| UniProt Synonym Protein Names: | PMMH-22 |
| Protein Family: | |
| UniProt Gene Name: | PMM1Â Â |
| UniProt Entry Name: | PMM1_HUMAN |
| Antibodies |
| PMM1 Antibody (PACO11317) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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