The PMM1 Polyclonal Antibody (PAC011317) is a valuable tool for researchers studying PMM1, an enzyme involved in carbohydrate metabolism. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for Western blot applications. By specifically binding to the PMM1 protein, this antibody enables accurate detection and analysis in various cell types, making it an excellent choice for studies in biochemistry and metabolic research.PMM1 is a phosphomannomutase enzyme that plays a key role in the phosphorylation of mannose, a critical step in glycosylation processes. Dysregulation of PMM1 has been linked to various metabolic disorders and diseases, making it a promising target for therapeutic interventions.
Understanding the function and regulation of PMM1 is crucial for developing treatments for conditions such as congenital disorders of glycosylation and metabolic syndromes.In summary, the PMM1 Polyclonal Antibody offers researchers a reliable tool for investigating the role of PMM1 in cellular metabolism and disease pathogenesis. Its specificity and sensitivity make it an essential component of any research project focusing on carbohydrate metabolism and related disorders.
PMM1: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. Belongs to the eukaryotic PMM family.Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; EC 5.4.2.8; IsomeraseChromosomal Location of Human Ortholog: 22q13.2Cellular Component: cytosolMolecular Function: phosphomannomutase activity; protein bindingBiological Process: GDP-mannose biosynthetic process; mannose metabolic process; protein amino acid N-linked glycosylation; protein targeting to ER
UniProt Protein Details:
NCBI Summary:
Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins. [provided by RefSeq, Jul 2008]
