The PML Rabbit Monoclonal Antibody (CAB19646) is a highly specific and sensitive research tool designed for the detection of PML protein in human samples. PML, also known as Promyelocytic Leukemia Protein, is a key player in various cellular processes, including apoptosis, senescence, and DNA damage response.Raised in rabbits, this antibody has been rigorously tested and validated for use in Western blot applications, ensuring accurate and reliable results. Its high reactivity with PML protein makes it an essential tool for studying the role of PML in cancer research, viral infections, and other diseases where PML dysregulation is implicated.
By enabling the detection and analysis of PML in different cell types, the PML Rabbit Monoclonal Antibody (CAB19646) is a valuable asset for researchers in the fields of oncology, virology, and molecular biology. Its versatility and specificity make it ideal for investigating the mechanisms underlying PML function and its potential as a therapeutic target in various pathological conditions.
Product Name:
PML Rabbit Monoclonal Antibody
SKU:
CAB19646
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PML (P29590).
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
5371
Clone Number:
ARC0125
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PML antibody (CAB19646) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
