The PML Isoform 5 Polyclonal Antibody (CAB18182) is a valuable tool for researchers studying the PML (Promyelocytic Leukemia) protein isoform 5. This protein plays a key role in regulating various cellular processes, including apoptosis, senescence, and DNA damage response.Raised in rabbits, this antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the PML Isoform 5 protein, this antibody enables the detection and analysis of this important molecule in a variety of cell types.
Research into PML Isoform 5 is critical for understanding its role in diseases such as cancer, where dysregulation of PML isoforms has been implicated in tumorigenesis and tumor progression. By studying the function of PML Isoform 5, researchers can gain insights into potential therapeutic targets for cancer treatment.Overall, the PML Isoform 5 Polyclonal Antibody is a valuable tool for researchers investigating the functions and mechanisms of PML isoform 5 in various cellular processes and disease contexts.
Product Name:
PML (isoform 5) Rabbit Polyclonal Antibody
SKU:
CAB18182
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 571-611 of human PML (NP_150241.2).
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
5371
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PML Rabbit pAb (CAB18182) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
