The PMAIP1 Polyclonal Antibody (CAB9801) is a valuable tool for researchers working with the PMAIP1 protein, also known as Noxa. This antibody, generated in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the PMAIP1 protein, this antibody allows for the detection and analysis of PMAIP1 expression in various cell types, making it ideal for studies in oncology and cell biology.PMAIP1, a pro-apoptotic protein, plays a crucial role in regulating programmed cell death by inducing mitochondrial membrane permeabilization. Its involvement in the intrinsic apoptosis pathway highlights its significance in cancer biology and potential as a therapeutic target.
Research into PMAIP1 can provide insights into mechanisms of cell death and potential strategies for developing novel cancer treatments targeting apoptosis.By using the PMAIP1 Polyclonal Antibody, researchers can delve into the function and regulation of PMAIP1, advancing our understanding of its role in cancer progression and its potential as a biomarker or therapeutic target. This antibody is a valuable tool for investigators exploring the intricacies of cell death pathways and molecular mechanisms underlying cancer development.
Product Name:
PMAIP1 Rabbit Polyclonal Antibody
SKU:
CAB9801
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-54 of human PMAIP1 (NP_066950.1).
This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic BCL-2 family members, which under steady-state conditions keep the multi-BH domain proteins BAX and BAK, in an inactive state.
Purification Method:
Affinity purification
Gene ID:
5366
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PMAIP1 Rabbit pAb (CAB9801) at 1:5000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
