The PLXNC1 Polyclonal Antibody (PAC059848) is a vital tool for researchers studying PLXNC1, a cell surface receptor associated with axon guidance and cell migration. This antibody, generated in rabbits, exhibits strong reactivity with human samples and is specially validated for use in immunohistochemistry and immunofluorescence assays. By targeting the PLXNC1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for investigations in developmental biology and cancer research.
PLXNC1, also known as plexin-C1, plays a crucial role in guiding the growth of nerve cells and regulating cell movement. Its involvement in these processes makes it a promising target for studying neurodevelopmental disorders, tumor progression, and metastasis. By gaining insights into the functions of PLXNC1, researchers can advance their understanding of these conditions and potentially develop new therapeutic strategies aimed at modulating nerve cell growth and migration.
Immunofluorescence staining of HepG2 cells with PACO59848 at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).
Synonyms:
Plexin-C1 (Virus-encoded semaphorin protein receptor) (CD antigen CD232), PLXNC1, VESPR
UniProt Protein Function:
PLXNC1: Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8. Belongs to the plexin family.Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesionChromosomal Location of Human Ortholog: 12q23.3Cellular Component: integral to plasma membrane; membrane; plasma membraneMolecular Function: protein binding; receptor binding; semaphorin receptor activityBiological Process: axon guidance; branchiomotor neuron axon guidance; cell adhesion; regulation of axon extension involved in axon guidance; regulation of cell migration
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
