The PLXNC1 Polyclonal Antibody (PACO06911) is a valuable tool for researchers studying PLXNC1, a transmembrane receptor involved in cell guidance and migration. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the PLXNC1 protein, this antibody allows for the detection and analysis of PLXNC1 expression in various cell types, making it ideal for research in cell biology, developmental biology, and cancer biology.PLXNC1, also known as Plexin-C1, plays a crucial role in axon guidance, cell migration, and angiogenesis, making it a key player in developmental processes and disease progression.
Its involvement in regulating cell behavior and tissue formation makes it a promising target for studies on neural development, cardiovascular diseases, and cancer metastasis. Understanding the function of PLXNC1 can provide insights into the mechanisms underlying these processes and may lead to the development of new therapeutic strategies targeting PLXNC1 signaling pathways.
Antibody Name:
PLXNC1 Antibody (PACO06911)
Antibody SKU:
PACO06911
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the Internal region of human CD232.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of NIH-3T3 cells using CD232 Polyclonal Antibody.
Western Blot analysis of 3T3 cells using CD232 Polyclonal Antibody.
Synonyms:
PLXNC1; VESPR; Plexin-C1; Virus-encoded semaphorin protein receptor; CD232
UniProt Protein Function:
PLXNC1: Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8. Belongs to the plexin family.Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesionChromosomal Location of Human Ortholog: 12q23.3Cellular Component: integral to plasma membrane; membrane; plasma membraneMolecular Function: protein binding; receptor binding; semaphorin receptor activityBiological Process: axon guidance; branchiomotor neuron axon guidance; cell adhesion; regulation of axon extension involved in axon guidance; regulation of cell migration
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
