The PLVAP Polyclonal Antibody (CAB15906) is a valuable tool for researchers studying PLVAP, a protein found in the endothelial cells of blood vessels and involved in regulating vascular permeability. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding to the PLVAP protein, researchers can investigate its role in various physiological and pathological conditions, particularly those related to vascular function and disease.PLVAP, also known as plasmalemmal vesicle-associated protein, is a key player in controlling the passage of molecules and cells across the endothelial barrier, making it a target of interest in studies on vascular biology, inflammation, and the development of therapies for conditions such as edema, tumor angiogenesis, and cardiovascular disease.
By understanding the functions and regulation of PLVAP, researchers can uncover new insights into vascular physiology and potential targets for therapeutic intervention.
Product Name:
PLVAP Rabbit Polyclonal Antibody
SKU:
CAB15906
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 63-442 of human PLVAP (NP_112600.1).
Cell membrane, Cytoplasm, Membrane, Single-pass type II membrane protein, caveola, perinuclear region.
Calculated MW:
51kDa
Observed MW:
55kDa
Predicted to enable identical protein binding activity. Involved in MAPK cascade; positive regulation of cellular extravasation; and tumor necrosis factor-mediated signaling pathway. Located in cell surface. Colocalizes with caveola. Implicated in congenital diarrhea.
Purification Method:
Affinity purification
Gene ID:
83483
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PLVAP Rabbit pAb (CAB15906) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
