The PLSCR1 Polyclonal Antibody (CAB6691) is a valuable tool for researchers studying phospholipid scramblase 1 (PLSCR1), a protein involved in various cellular processes such as apoptosis, cell proliferation, and immune response. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By targeting the PLSCR1 protein, this antibody enables the detection and analysis of PLSCR1 in a variety of cell types, making it suitable for research in immunology, cancer biology, and cell signaling pathways.PLSCR1 is a multifunctional protein that plays a crucial role in various cellular functions, including the externalization of phosphatidylserine during apoptosis and the regulation of immune responses.
Studies have shown that dysregulation of PLSCR1 is associated with autoimmune diseases, cancer progression, and inflammatory disorders. Therefore, understanding the function and regulation of PLSCR1 is essential for developing targeted therapies for these conditions.Overall, the PLSCR1 Polyclonal Antibody (CAB6691) is a powerful tool for researchers looking to investigate the role of PLSCR1 in cellular processes and disease pathogenesis. Its high specificity and reactivity make it a reliable choice for studying PLSCR1 in a variety of experimental contexts.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human Phospholipid Scramblase 1 (Phospholipid Scramblase 1 (PLSCR1)) (NP_066928.1).
Cell membrane, Cytoplasmic side, Lipid-anchor, Membrane, Nucleus, Single-pass type II membrane protein.
Calculated MW:
35kDa
Observed MW:
35kDa
This gene encodes a phospholipid scramblase family member. The encoded protein is involved in disruption of the asymmetrical distribution of phospholipids between the inner and outer leaflets of the plasma membrane, resulting in externalization of phosphatidylserine. This cell membrane disruption plays an important role in the blood coagulation cascade as well as macrophage clearing of apoptotic cells. The encoded protein has additionally been implicated in gene regulation and interferon-induced antiviral responses.
Purification Method:
Affinity purification
Gene ID:
5359
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Phospholipid Scramblase 1 (Phospholipid Scramblase 1 (PLSCR1)) antibody (CAB6691) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
