The PLPPR2 Polyclonal Antibody (PAC029164) is a valuable tool for researchers studying PLPPR2, a membrane glycoprotein involved in lipid metabolism and cell signaling pathways. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting PLPPR2 in human samples, making it suitable for use in Western blot applications. By binding to the PLPPR2 protein, this antibody allows for the accurate identification and analysis of PLPPR2 expression in various cell types, making it an essential component for studies in areas such as lipid biology and signal transduction.
PLPPR2, also known as Phospholipid Phosphatase-related protein type 2, is known to play a key role in regulating intracellular lipid levels and influencing cellular responses to external stimuli. Its involvement in lipid metabolism and signaling processes makes it a promising target for research in fields like lipidomics, neurobiology, and metabolic disorders. By elucidating the functions of PLPPR2, researchers can gain insights into diseases related to lipid dysregulation and potentially identify novel therapeutic strategies for treating these conditions.
Immunohistochemistry of paraffin-embedded human liver tissue using PACO29164 at dilution of 1:100.
Immunofluorescent analysis of Hela cells using PACO29164 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.
Synonyms:
Phospholipid phosphatase-related protein type 2 (EC 3.1.3.4) (Lipid phosphate phosphatase-related protein type 2) (Plasticity-related gene 4 protein) (PRG-4), PLPPR2, LPPR2 PRG4
UniProt Protein Function:
Catalytic activity: A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.Subcellular location: Membrane; Multi-pass membrane protein Potential. Sequence similarities: Belongs to the PA-phosphatase related phosphoesterase family.
