The PLPPR1 Polyclonal Antibody (PAC06475) is a valuable tool for researchers studying PLPPR1, a protein involved in lipid metabolism and neuronal function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the PLPPR1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it particularly suitable for investigations in neuroscience and lipid biology.PLPPR1, also known as lipid phosphate phosphohydrolase-related protein 1, plays a crucial role in lipid signaling pathways and neuronal development.
Its functions are implicated in processes such as synaptic plasticity, memory formation, and neuroinflammation. Research into the mechanisms of PLPPR1 can provide insights into neurological disorders, neurodegenerative diseases, and lipid-related conditions, offering potential therapeutic targets for drug development and treatment strategies. Understanding the role of PLPPR1 is essential for advancing knowledge in these areas and developing interventions to address associated health challenges.
Antibody Name:
PLPPR1 Antibody (PACO64475)
Antibody SKU:
PACO64475
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Peptide sequence from Human Phospholipid phosphatase-related protein type 1 protein (51-66AA)
IHC image of PACO64475 diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
Background:
integral component of plasma membrane, nucleoplasm, lipid phosphatase activity, phosphatidate phosphatase activity, phospholipid dephosphorylation, phospholipid metabolic process, signal transduction
Synonyms:
Phospholipid phosphatase-related protein type 1 (Lipid phosphate phosphatase-related protein type 1) (Plasticity-related gene 3 protein) (PRG-3), PLPPR1, LPPR1 PRG3
UniProt Protein Function:
PRG-3: a member of the plasticity-related gene (PRG) family. Members of the PRG family mediate lipid phosphate phosphatase activity in neurons and are known to be involved in neuronal plasticity. The protein encoded by this gene does not perform its function through enzymatic phospholipid degradation. This gene is strongly expressed in brain. It shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 9q31.1Cellular Component: integral to plasma membraneMolecular Function: lipid phosphatase activityBiological Process: nervous system development; phospholipid dephosphorylation; phospholipid metabolic process; signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the plasticity-related gene (PRG) family. Members of the PRG family mediate lipid phosphate phosphatase activity in neurons and are known to be involved in neuronal plasticity. The protein encoded by this gene does not perform its function through enzymatic phospholipid degradation. This gene is strongly expressed in brain. It shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
