The PLP1/PMP22 Polyclonal Antibody (PAC064471) is a valuable tool for researchers studying the PLP1 protein, which is essential for the structure and function of myelin in the central nervous system. This antibody, derived from rabbit serum, exhibits strong reactivity with human samples and is suitable for use in Western blot applications.PLP1, a major component of myelin in the brain and spinal cord, is crucial for the proper transmission of signals along nerve fibers. Mutations in the PLP1 gene are associated with disorders like Pelizaeus-Merzbacher disease, a rare neurological disorder that affects the formation of myelin.
By targeting the PLP1 protein, researchers can investigate its role in myelin formation, maintenance, and function, providing insights into the pathophysiology of demyelinating diseases.With its specificity for PLP1, the PAC064471 antibody enables the detection and analysis of this important protein in various cell types and tissues. This makes it an indispensable tool for studies exploring myelin biology, neurodevelopmental disorders, and demyelinating diseases, offering new avenues for targeted therapeutic interventions in conditions affecting the nervous system.
Antibody Name:
PLPPR1 Antibody (PACO64471)
Antibody SKU:
PACO64471
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
IF:1:100-1:500
Species Reactivity:
Human
Immunogen:
Peptide sequence from Human Phospholipid phosphatase-related protein type 1 protein (51-66AA)
Immunofluorescence staining of HepG2 cells with PACO64471 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
integral component of plasma membrane, nucleoplasm, lipid phosphatase activity, phosphatidate phosphatase activity, phospholipid dephosphorylation, phospholipid metabolic process, signal transduction
Synonyms:
Phospholipid phosphatase-related protein type 1 (Lipid phosphate phosphatase-related protein type 1) (Plasticity-related gene 3 protein) (PRG-3), PLPPR1, LPPR1 PRG3
UniProt Protein Function:
PRG-3: a member of the plasticity-related gene (PRG) family. Members of the PRG family mediate lipid phosphate phosphatase activity in neurons and are known to be involved in neuronal plasticity. The protein encoded by this gene does not perform its function through enzymatic phospholipid degradation. This gene is strongly expressed in brain. It shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 9q31.1Cellular Component: integral to plasma membraneMolecular Function: lipid phosphatase activityBiological Process: nervous system development; phospholipid dephosphorylation; phospholipid metabolic process; signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the plasticity-related gene (PRG) family. Members of the PRG family mediate lipid phosphate phosphatase activity in neurons and are known to be involved in neuronal plasticity. The protein encoded by this gene does not perform its function through enzymatic phospholipid degradation. This gene is strongly expressed in brain. It shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
