The PLP1 Polyclonal Antibody (CAB14251) is a valuable tool for researchers studying PLP1, a key protein involved in the structure and function of myelin in the central nervous system. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.PLP1, also known as proteolipid protein 1, is essential for the formation and maintenance of myelin sheaths, which insulate nerve fibers and facilitate efficient transmission of electrical impulses. Dysregulation of PLP1 is associated with demyelinating diseases such as Pelizaeus-Merzbacher disease and multiple sclerosis, highlighting the importance of studying this protein in neurological research.
By targeting the PLP1 protein, researchers can gain insights into myelin-related disorders and potentially identify novel therapeutic targets for treating these debilitating conditions. The PLP1 Polyclonal Antibody is a reliable tool for investigating the role of PLP1 in health and disease, making it a valuable asset for studies in neurology and neurodegenerative diseases.
Product Name:
PLP1 Rabbit Polyclonal Antibody
SKU:
CAB14251
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 102-148 of human PLP1 (NP_955772.1).
This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant.
Purification Method:
Affinity purification
Gene ID:
5354
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PLP1 Rabbit pAb (CAB14251) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
