PLOD2 Rabbit Polyclonal Antibody (CAB6946)
- SKU:
- CAB6946
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | PLOD2 Rabbit Polyclonal Antibody |
SKU: | CAB6946 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-380 of human PLOD2/LH2 (NP_000926.2). |
Sequence: | ILLN YFGN YVPN SWTQ DNGC TLCE FDTV DLSA VDVH PNVS IGVF IEQP TPFL PRFL DILL TLDY PKEA LKLF IHNK EVYH EKDI KVFF DKAK HEIK TIKI VGPE ENLS QAEA RNMG MDFC R |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | LH2; TLH; BRKS2; PLOD2/LH2 |
Positive Sample: | DU145,U-87MG,Molt-4,Mouse uterus,Rat uterus |
Conjugate: | Unconjugated |
Cellular Localization: | Lumenal side, Peripheral membrane protein, Rough endoplasmic reticulum membrane. |
Calculated MW: | 85kDa |
Observed MW: | 100kDa |
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 5352 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |