PLK3 Rabbit Polyclonal Antibody (CAB8674)
- SKU:
- CAB8674
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Product Name: | PLK3 Rabbit Polyclonal Antibody |
SKU: | CAB8674 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 487-646 of human PLK3 (NP_004064.2). |
Sequence: | VLFN DGTH MALS ANRK TVHY NPTS TKHF SFSV GAVP RALQ PQLG ILRY FASY MEQH LMKG GDLP SVEE VEVP APPL LLQW VKTD QALL MLFS DGTV QVNF YGDH TKLI LSGW EPLL VTFV ARNR SACT YLAS HLRQ LGCS PDLR QRLR YALR LLRD RSPA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | CNK; FNK; PRK; PLK-3; PLK3 |
Positive Sample: | HeLa,Mouse large intestine,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Golgi apparatus, Nucleus, centrosome, cytoskeleton, microtubule organizing center, nucleolus. |
Calculated MW: | 72kDa |
Observed MW: | 72kDa |
The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis.
Purification Method: | Affinity purification |
Gene ID: | 1263 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |