The PLK1 Polyclonal Antibody (CAB2548) is a valuable tool for researchers studying PLK1, a key regulator of cell division and a potential target for cancer therapy. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the PLK1 protein, the antibody enables researchers to detect and analyze PLK1 expression in a variety of cell types, making it ideal for investigations in oncology and cell biology.PLK1, also known as polo-like kinase 1, plays a crucial role in regulating mitosis and cytokinesis, and dysregulation of PLK1 has been linked to tumorigenesis and cancer progression.
As a promising target for cancer treatment, understanding the function of PLK1 is essential for developing novel therapies that target cell cycle checkpoints and inhibit tumor growth.Overall, the PLK1 Polyclonal Antibody (CAB2548) offers researchers a reliable tool for investigating the function and expression of PLK1 in cancer biology and may contribute to the development of new therapeutic strategies for treating cancer.
Product Name:
PLK1 Rabbit Polyclonal Antibody
SKU:
CAB2548
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 304-603 of human PLK1 (NP_005021.2).
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy.
Purification Method:
Affinity purification
Gene ID:
5347
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PLK1 Rabbit pAb (CAB2548) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
