The PLIN4 Polyclonal Antibody (PAC052558) is a valuable tool for researchers studying the role of PLIN4 in lipid metabolism and obesity-related diseases. PLIN4, a member of the perilipin family, plays a key role in regulating lipid droplet formation and metabolism in adipocytes. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blotting.By binding to the PLIN4 protein, this antibody allows for the detection and analysis of PLIN4 expression in different cell types, providing valuable insights into its function in lipid storage and energy homeostasis.
Research into PLIN4 holds promise for understanding the mechanisms underlying obesity, metabolic disorders, and potential targets for therapeutic interventions.Overall, the PLIN4 Polyclonal Antibody is a crucial tool for researchers interested in delving deeper into the role of PLIN4 in lipid metabolism and its implications for human health and disease.
Western Blot. Positive WB detected in: A549 whole cell lysate. All lanes: PLIN4 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 135, 141 kDa. Observed band size: 135 kDa.
Immunofluorescent analysis of PC-3 cells using PACO52558 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO52558 at dilution of 1:100.
Background:
May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity).
Synonyms:
Perilipin-4 (Adipocyte protein S3-12), PLIN4, KIAA1881
UniProt Protein Function:
perilipin 4: May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets. Belongs to the perilipin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 19p13.3Cellular Component: cytoplasm; intracellular membrane-bound organelle; lipid particle; plasma membrane
UniProt Protein Details:
NCBI Summary:
Members of the perilipin family, such as PLIN4, coat intracellular lipid storage droplets (Wolins et al., 2003 [PubMed 12840023]).[supplied by OMIM, Feb 2010]
