The PLIN3 Polyclonal Antibody (CAB15776) is a valuable tool for researchers studying PLIN3, a protein involved in lipid metabolism and storage within cells. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the PLIN3 protein, this antibody enables researchers to detect and analyze PLIN3 expression in various cell types, providing important insights into lipid storage mechanisms and potential therapeutic targets for metabolic disorders.
PLIN3, also known as perilipin-3, plays a crucial role in regulating lipid droplet formation and metabolism, making it a key player in cellular energy homeostasis. Dysregulation of PLIN3 has been linked to disorders such as obesity, diabetes, and fatty liver disease, highlighting its importance in metabolic health. By studying the function of PLIN3, researchers can uncover new pathways for treating and preventing these metabolic conditions, ultimately improving human health outcomes.
Product Name:
PLIN3 Rabbit Polyclonal Antibody
SKU:
CAB15776
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 135-434 of human PLIN3 (NP_005808.3).
Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10226
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PLIN3 Rabbit pAb (CAB15776) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
