The PLIN3 Polyclonal Antibody (CAB1050) is a valuable tool for researchers studying the PLIN3 protein, which plays a crucial role in lipid metabolism and storage. This antibody, generated in rabbits, is highly specific and reactive with human samples, making it suitable for use in Western blot applications. By binding to the PLIN3 protein, this antibody enables researchers to detect and analyze the protein in various cell types, making it ideal for studies in metabolism, obesity, and related diseases.PLIN3, also known as perilipin-3, is a key regulator of lipid droplet formation and breakdown in cells, influencing processes such as adipocyte differentiation and lipid metabolism.
Dysregulation of PLIN3 has been linked to disorders like obesity, insulin resistance, and fatty liver disease, highlighting its importance in maintaining metabolic homeostasis. By investigating the role of PLIN3 in these conditions, researchers can gain valuable insights into potential therapeutic targets and interventions for metabolic disorders.
Product Name:
PLIN3 Rabbit Polyclonal Antibody
SKU:
CAB1050
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 135-434 of human PLIN3 (NP_005808.3).
Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10226
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PLIN3 Rabbit pAb (CAB1050) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
