The PLET1 Polyclonal Antibody (PACO39738) is a valuable tool for researchers studying PLET1, a protein involved in cell adhesion and migration processes. This antibody, generated in rabbits, shows high specificity and reactivity with human samples, making it suitable for use in Western blot and immunohistochemistry applications. By binding to the PLET1 protein, this antibody allows for the detection and analysis of PLET1 expression in various cell types, providing insights into its role in cellular dynamics.PLET1, also known as Placenta Expressed Transcript 1, is key in mediating cell-cell interactions and influencing cell motility, making it a potential target for investigations in developmental biology and cancer research.
Its involvement in regulating cellular behavior highlights its importance in understanding processes such as tissue morphogenesis and metastasis. Researchers studying PLET1 can gain insights that may lead to the development of new therapeutic strategies for conditions associated with aberrant cell adhesion and migration.
Western blot. All lanes: Plet1 antibody at 5µg/ml. Lane 1: L929 whole cell lysate. Lane 2: U251 whole cell lysate. Lane 3: Mouse muscle tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 26, 21 kDa. Observed band size: 26 kDa.
Immunohistochemistry of paraffin-embedded human breast cancer using PACO39738 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO39738 at dilution of 1:100.
Background:
Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle.
Synonyms:
Placenta-expressed transcript 1 protein (Antigen mAgK114), Plet1
UniProt Protein Function:
PLET1: May participate in the wound response during the healing process, and promote wound repair.Protein type: Membrane protein, GPI anchor; Membrane protein, integralCellular Component: apical plasma membrane; external side of plasma membraneBiological Process: negative regulation of cell-matrix adhesion; positive regulation of cell migration; wound healing, spreading of epidermal cells
