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PLEKHO1 Antibody (PACO48634)

SKU:
PACO48634
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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PLEKHO1 Antibody (PACO48634)

The Plekho1 Polyclonal Antibody (PAC048634) is an essential tool for researchers studying the Plekho1 protein, which plays a key role in cellular processes related to cell polarity and membrane trafficking. This antibody, produced in rabbits, demonstrates high specificity and sensitivity in detecting Plekho1 in human samples, making it an ideal choice for Western blot analysis.Plekho1 is known for its involvement in regulating cell polarization and membrane dynamics, processes that are vital for various cellular functions such as cell migration and vesicle trafficking.

Dysregulation of Plekho1 has been linked to diseases like cancer, where abnormal cell polarity and membrane trafficking can contribute to tumor growth and metastasis. By understanding the role of Plekho1 in these processes, researchers can gain valuable insights for developing targeted therapies for cancer and other related conditions.

Antibody Name:PLEKHO1 Antibody (PACO48634)
Antibody SKU:PACO48634
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Pleckstrin homology domain-containing family O member 1 protein (143-404AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunofluorescent analysis of Hela cells using PACO48634 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Synonyms:Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein), PLEKHO1, CKIP1 OC120
UniProt Protein Function:PLEKHO1: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT- mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Tumor suppressor

Chromosomal Location of Human Ortholog: 1q21.2

Molecular Function:protein binding

UniProt Code:Q53GL0
NCBI GenInfo Identifier:160419242
NCBI Gene ID:51177
NCBI Accession:Q53GL0.2
UniProt Secondary Accession:Q53GL0,Q336K5, Q8IZ51, Q9NRV3, Q9UL48,
UniProt Related Accession:Q53GL0
Molecular Weight:42,330 Da
NCBI Full Name:Pleckstrin homology domain-containing family O member 1
NCBI Synonym Full Names:pleckstrin homology domain containing O1
NCBI Official Symbol:PLEKHO1  
NCBI Official Synonym Symbols:JBP; CKIP1; OC120; CKIP-1  
NCBI Protein Information:pleckstrin homology domain-containing family O member 1
UniProt Protein Name:Pleckstrin homology domain-containing family O member 1
UniProt Synonym Protein Names:C-Jun-binding protein; JBP; Casein kinase 2-interacting protein 1; CK2-interacting protein 1; CKIP-1; Osteoclast maturation-associated gene 120 protein
Protein Family:Pleckstrin homology domain-containing family
UniProt Gene Name:PLEKHO1  
UniProt Entry Name:PKHO1_HUMAN
ELISA Kits
Human PLEKHO1 / Pleckstrin homology domain-containing family O member 1 ELISA Kit
Human Pleckstrin homology domain-containing family O member 1 (PLEKHO1) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
Recommended Products
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

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