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PLEKHO1 Antibody (PACO17709)

SKU:
PACO17709
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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PLEKHO1 Antibody (PACO17709)

The Plekho1 Polyclonal Antibody (PAC017709) is a valuable tool for research involving Plekho1, a protein involved in cell signaling pathways and membrane dynamics. This antibody, raised in rabbits, is highly specific to Plekho1 and can be used in a variety of applications including Western blot, immunofluorescence, and immunohistochemistry.Plekho1 plays a critical role in regulating cell polarity, cell migration, and vesicle trafficking, making it an important target for studies in cell biology and cancer research. By targeting Plekho1 with this antibody, researchers can investigate its function and localization in different cell types, shedding light on its role in various physiological and pathological processes.

Overall, the Plekho1 Polyclonal Antibody (PAC017709) is a reliable tool for exploring the intricacies of Plekho1 biology and its implications in cellular functions and disease states. Its high specificity and versatility in different assay formats make it a valuable asset for researchers looking to unravel the complexities of Plekho1 signaling pathways.

Antibody Name:PLEKHO1 Antibody (PACO17709)
Antibody SKU:PACO17709
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:Human, Mouse, Rat
Immunogen:Synthetic peptide of human PLEKHO1
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO17709(PLEKHO1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by the PLEKHO1 gene.PLEKHO1 has been shown to interact with Casein kinase 2, α 1 and SMURF1.It plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). Appears to target ATM to the plasma membrane,and also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. The protein implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Synonyms:pleckstrin homology domain containing, family O member 1
UniProt Protein Function:PLEKHO1: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT- mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Tumor suppressor

Chromosomal Location of Human Ortholog: 1q21.2

Molecular Function:protein binding

UniProt Code:Q53GL0
NCBI GenInfo Identifier:160419242
NCBI Gene ID:51177
NCBI Accession:Q53GL0.2
UniProt Secondary Accession:Q53GL0,Q336K5, Q8IZ51, Q9NRV3, Q9UL48,
UniProt Related Accession:Q53GL0
Molecular Weight:42,330 Da
NCBI Full Name:Pleckstrin homology domain-containing family O member 1
NCBI Synonym Full Names:pleckstrin homology domain containing O1
NCBI Official Symbol:PLEKHO1  
NCBI Official Synonym Symbols:JBP; CKIP1; OC120; CKIP-1  
NCBI Protein Information:pleckstrin homology domain-containing family O member 1
UniProt Protein Name:Pleckstrin homology domain-containing family O member 1
UniProt Synonym Protein Names:C-Jun-binding protein; JBP; Casein kinase 2-interacting protein 1; CK2-interacting protein 1; CKIP-1; Osteoclast maturation-associated gene 120 protein
Protein Family:Pleckstrin homology domain-containing family
UniProt Gene Name:PLEKHO1  
UniProt Entry Name:PKHO1_HUMAN
ELISA Kits
Human PLEKHO1 / Pleckstrin homology domain-containing family O member 1 ELISA Kit
Human Pleckstrin homology domain-containing family O member 1 (PLEKHO1) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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