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PLEKHO1 Antibody (PACO16039)

SKU:
PACO16039
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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PLEKHO1 Antibody (PACO16039)

The Plekho1 Antibody (PACO16039) is a valuable tool for researchers studying Pleckstrin homology domain-containing family O member 1 (Plekho1), a protein involved in regulating cell migration and membrane dynamics. This antibody, produced through immunization of rabbits, exhibits high specificity and sensitivity to human samples, making it suitable for use in various research applications such as Western blotting and immunofluorescence.Plekho1 is known to play a crucial role in cell signaling pathways that control cell movement and shape, making it a key player in processes like wound healing and cancer metastasis.

By targeting Plekho1 with this antibody, researchers can gain insights into its function and potential therapeutic implications in diseases related to abnormal cell motility.This antibody is a valuable tool for investigating the role of Plekho1 in cellular processes and disease pathogenesis, offering researchers the opportunity to deepen their understanding of this protein and its potential as a target for therapeutic interventions.

Antibody Name:PLEKHO1 Antibody (PACO16039)
Antibody SKU:PACO16039
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:Human, Mouse, Rat
Immunogen:Fusion protein of human PLEKHO1
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16039(PLEKHO1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by thePLEKHO1 gene. Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF.
Synonyms:pleckstrin homology domain containing, family O member 1
UniProt Protein Function:PLEKHO1: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT- mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Tumor suppressor

Chromosomal Location of Human Ortholog: 1q21.2

Molecular Function:protein binding

UniProt Code:Q53GL0
NCBI GenInfo Identifier:160419242
NCBI Gene ID:51177
NCBI Accession:Q53GL0.2
UniProt Secondary Accession:Q53GL0,Q336K5, Q8IZ51, Q9NRV3, Q9UL48,
UniProt Related Accession:Q53GL0
Molecular Weight:42,330 Da
NCBI Full Name:Pleckstrin homology domain-containing family O member 1
NCBI Synonym Full Names:pleckstrin homology domain containing O1
NCBI Official Symbol:PLEKHO1  
NCBI Official Synonym Symbols:JBP; CKIP1; OC120; CKIP-1  
NCBI Protein Information:pleckstrin homology domain-containing family O member 1
UniProt Protein Name:Pleckstrin homology domain-containing family O member 1
UniProt Synonym Protein Names:C-Jun-binding protein; JBP; Casein kinase 2-interacting protein 1; CK2-interacting protein 1; CKIP-1; Osteoclast maturation-associated gene 120 protein
Protein Family:Pleckstrin homology domain-containing family
UniProt Gene Name:PLEKHO1  
UniProt Entry Name:PKHO1_HUMAN
ELISA Kits
Human PLEKHO1 / Pleckstrin homology domain-containing family O member 1 ELISA Kit
Human Pleckstrin homology domain-containing family O member 1 (PLEKHO1) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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