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PLEKHO1 Antibody (PACO16038)

SKU:
PACO16038
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • PLEKHO1 Antibody PACO16038
  • PLEKHO1 Antibody PACO16038
  • PLEKHO1 Antibody PACO16038
€339
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Description

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PLEKHO1 Antibody (PACO16038)

The Plekho1 Polyclonal Antibody (PAC016038) is a valuable tool for researchers studying Plekho1, a protein involved in cell signaling and membrane dynamics. This rabbit-derived antibody is highly specific to Plekho1 in human samples and has been validated for use in Western blot applications. By binding to Plekho1, researchers can detect and analyze the protein in various cell types, making it an essential tool for studies in molecular biology and cell signaling pathways.Plekho1 is a key regulator of cell polarity and membrane trafficking, playing a crucial role in processes such as cell migration and vesicle trafficking.

Its involvement in these cellular functions makes it a target of interest for research in cancer biology, developmental biology, and neurobiology. Understanding the role of Plekho1 can provide insights into disease mechanisms and potential therapeutic targets for various disorders.Overall, the Plekho1 Polyclonal Antibody is a high-quality reagent that enables accurate detection and analysis of Plekho1 protein, making it an invaluable asset for scientists investigating cellular processes and disease pathways.

Antibody Name:PLEKHO1 Antibody (PACO16038)
Antibody SKU:PACO16038
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:Fusion protein of human PLEKHO1
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16038(PLEKHO1 Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: x200).
Product ImageGel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela cells, mouse muscle tissue, Mouse kidney tissue, Primary antibody: PACO16038(PLEKHO1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16038(PLEKHO1 Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: x200).
Background:Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by thePLEKHO1 gene. Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival.
Synonyms:pleckstrin homology domain containing, family O member 1
UniProt Protein Function:PLEKHO1: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT- mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Tumor suppressor

Chromosomal Location of Human Ortholog: 1q21.2

Molecular Function:protein binding

UniProt Code:Q53GL0
NCBI GenInfo Identifier:160419242
NCBI Gene ID:51177
NCBI Accession:Q53GL0.2
UniProt Secondary Accession:Q53GL0,Q336K5, Q8IZ51, Q9NRV3, Q9UL48,
UniProt Related Accession:Q53GL0
Molecular Weight:42,330 Da
NCBI Full Name:Pleckstrin homology domain-containing family O member 1
NCBI Synonym Full Names:pleckstrin homology domain containing O1
NCBI Official Symbol:PLEKHO1  
NCBI Official Synonym Symbols:JBP; CKIP1; OC120; CKIP-1  
NCBI Protein Information:pleckstrin homology domain-containing family O member 1
UniProt Protein Name:Pleckstrin homology domain-containing family O member 1
UniProt Synonym Protein Names:C-Jun-binding protein; JBP; Casein kinase 2-interacting protein 1; CK2-interacting protein 1; CKIP-1; Osteoclast maturation-associated gene 120 protein
Protein Family:Pleckstrin homology domain-containing family
UniProt Gene Name:PLEKHO1  
UniProt Entry Name:PKHO1_HUMAN
ELISA Kits
Human PLEKHO1 / Pleckstrin homology domain-containing family O member 1 ELISA Kit
Human Pleckstrin homology domain-containing family O member 1 (PLEKHO1) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
Recommended Products
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

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