The Plekha8 Polyclonal Antibody (PAC011297) is a powerful tool for researchers studying Plekha8, a protein involved in cell adhesion and signaling pathways. This antibody, produced in rabbits, shows high specificity for Plekha8 in human samples and is validated for use in various applications, including Western blot and immunofluorescence.Plekha8, also known as pleckstrin homology domain-containing family A member 8, is a key player in cellular processes such as cell migration, proliferation, and differentiation. Its role in cancer progression and metastasis makes it a promising target for cancer research.
By targeting Plekha8 with this antibody, researchers can gain valuable insights into its function and potential therapeutic applications in oncology.In addition, Plekha8 has been implicated in other pathologies such as cardiovascular diseases and neurological disorders, highlighting its diverse roles in human health. The use of the PAC011297 antibody in research can provide essential data for understanding Plekha8's mechanisms of action and its implications in various disease contexts.
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8;PLEKHA8;FAPP2;MGC3358 ;
UniProt Protein Function:
PLEKHA8: Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 7p14.3Cellular Component: trans-Golgi networkMolecular Function: glycolipid binding; glycolipid transporter activityBiological Process: lipid transport
Pleckstrin homology domain-containing family A member 8
NCBI Synonym Full Names:
pleckstrin homology domain containing A8
NCBI Official Symbol:
PLEKHA8Â Â
NCBI Official Synonym Symbols:
FAPP2Â Â
NCBI Protein Information:
pleckstrin homology domain-containing family A member 8
UniProt Protein Name:
Pleckstrin homology domain-containing family A member 8
UniProt Synonym Protein Names:
Phosphatidylinositol-four-phosphate adapter protein 2; FAPP-2; Phosphoinositol 4-phosphate adapter protein 2; hFAPP2; Serologically defined breast cancer antigen NY-BR-86
