The Plectin Monoclonal Antibody offered by AssayGenie (AG-CAB-1465) is a versatile tool for researchers studying the protein plectin, an essential component of the cytoskeleton involved in cell adhesion and migration processes. This antibody, produced using innovative monoclonal antibody technology, exhibits high specificity and sensitivity in detecting plectin in human samples, making it a valuable asset for a wide range of research applications.Plectin is a key player in maintaining cell structure and integrity, and dysregulation of its function has been linked to various diseases, including muscular dystrophy and skin disorders.
By targeting plectin, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets.With its superior performance in techniques such as Western blotting and immunofluorescence, the Plectin Monoclonal Antibody from AssayGenie enables precise and reliable detection of plectin in diverse cell types and experimental settings. This antibody is a valuable tool for advancing research in cell biology, molecular biology, and disease pathology, providing researchers with the means to deepen their understanding of plectin's role in health and disease.
cytoplasm, cytosol, extracellular exosome, focal adhesion, intermediate filament cytoskeleton, mitochondrial outer membrane, perinuclear region of cytoplasm, plasma membrane, Z disc
Calculated MW:
532kDa
Observed MW:
Refer to figures
Plectin is a large, widely expressed protein that crosslinks the intermediate filament and actin cytoskeleton, mechanically stabilizing cells and tissues. Plectin also plays a role in the regulation of actin dynamics and acts as a scaffold for signaling molecules. Plectin is important in the stabilization of hemidesmosomes, crosslinking them to the intermediate filament network. Research studies have shown that mutations in plectin and other genes coding for hemidesmosomal proteins can cause epidermolysis bullosa, a condition manifested by fragile skin and frequent blistering . Plectin modulates signals to PKC through binding and sequestration of RACK1, the receptor for activated C kinase 1 . Plectin is also involved in the regulation of cytokeratin architecture and cell stress response , signaling through the chemokine receptor CXCR4 and regulation of AMP-activated protein kinase (AMPK) activity and signaling in mouse myotubes .
Purification Method:
Affinity purification
Gene ID:
5339
Clone Number:
ARC53240
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat stomach using Plectin Rabbit mAb (CAB23479) at dilution of 1:1000 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
