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PLCZ1 Antibody (PACO16874)

SKU:
PACO16874
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339

Description

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PLCZ1 Antibody (PACO16874)

The PLCz1 Polyclonal Antibody (PACO16874) is a valuable tool for researchers studying PLCz1, a key protein involved in cell signaling pathways and calcium release. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting and immunofluorescence applications.PLCz1, also known as phospholipase C zeta 1, is essential for triggering the release of calcium ions within cells, a crucial process in many biological functions including fertilization and embryonic development. Dysregulation of PLCz1 has been linked to various diseases, making it an important target for research in areas such as reproductive health and cancer.

The PLCz1 Polyclonal Antibody provides researchers with a reliable tool to study the expression and localization of PLCz1 in different cell types, helping to further our understanding of its role in cellular signaling and disease pathology. Its specificity and versatility make it a valuable asset for studies aiming to uncover the mechanisms underlying various physiological and pathological processes.

Antibody Name:PLCZ1 Antibody (PACO16874)
Antibody SKU:PACO16874
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:Human
Immunogen:Fusion protein of human PLCZ1
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO16874(PLCZ1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants.
Synonyms:phospholipase C, zeta 1
UniProt Protein Function:PLCZ1: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; PhospholipaseChromosomal Location of Human Ortholog: 12p12.3Cellular Component: perinuclear region of cytoplasm; nucleus; cytosolMolecular Function: signal transducer activity; calcium ion binding; phosphoinositide phospholipase C activityBiological Process: inositol phosphate metabolic process; multicellular organismal development; calcium ion transport; egg activation; lipid catabolic process
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
UniProt Code:Q86YW0
NCBI GenInfo Identifier:74714209
NCBI Gene ID:89869
NCBI Accession:Q86YW0.1
UniProt Secondary Accession:Q86YW0,Q08AQ7, Q96J70
UniProt Related Accession:Q86YW0
Molecular Weight:57,804 Da
NCBI Full Name:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
NCBI Synonym Full Names:phospholipase C, zeta 1
NCBI Official Symbol:PLCZ1  
NCBI Official Synonym Symbols:PLCzeta; NYD-SP27; PLC-zeta-1  
NCBI Protein Information:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; PI-phospholipase C zeta 1; testis-development related NYD-SP27; phosphoinositide phospholipase C-zeta-1
UniProt Protein Name:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
UniProt Synonym Protein Names:Phosphoinositide phospholipase C-zeta-1; Phospholipase C-zeta-1; PLC-zeta-1; Testis-development protein NYD-SP27
Protein Family:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
UniProt Gene Name:PLCZ1  
UniProt Entry Name:PLCZ1_HUMAN
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