The PLCH1 Polyclonal Antibody (CAB12903) is specifically designed for research involving PLCH1, a protein involved in cellular signaling pathways related to the phosphoinositide pathway. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the PLCH1 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential tool for studies in cell signaling, cancer research, and other related fields.PLCH1, also known as phospholipase C-like protein 1, plays a crucial role in the regulation of intracellular calcium levels and cellular signaling cascades.
Its involvement in cellular processes such as cell proliferation, migration, and differentiation makes it a promising target for investigating diseases like cancer, neurodegenerative disorders, and cardiovascular diseases. Understanding the functions and mechanisms of PLCH1 is essential for developing targeted therapies that aim to manipulate these signaling pathways for therapeutic purposes.Overall, the PLCH1 Polyclonal Antibody (CAB12903) offers researchers a valuable tool for investigating the role of PLCH1 in various biological processes and diseases, ultimately contributing to the advancement of scientific knowledge and the development of novel treatment strategies.
Product Name:
PLCH1 Rabbit Polyclonal Antibody
SKU:
CAB12903
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1100-1400 of human PLCH1 (NP_055811.1).
PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).
Purification Method:
Affinity purification
Gene ID:
23007
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from rat brain, using PLCH1 Rabbit pAb (CAB12903) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
