The PLCG2 Polyclonal Antibody (CAB2182) is a valuable tool for researchers studying PLCG2, a key enzyme involved in immune signaling pathways. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By targeting the PLCG2 protein, this antibody enables researchers to analyze and detect PLCG2 expression in a wide range of cell types, making it an essential tool for studies in immunology, inflammation, and autoimmune diseases.PLCG2, also known as phospholipase C gamma 2, plays a crucial role in immune cell activation and the regulation of inflammatory responses. Dysregulation of PLCG2 activity has been linked to various autoimmune disorders, allergies, and inflammatory conditions, making it a promising target for therapeutic interventions.
By gaining a deeper understanding of PLCG2 function, researchers can potentially develop novel treatments for diseases associated with dysregulated immune responses.Overall, the PLCG2 Polyclonal Antibody is a valuable resource for researchers looking to explore the role of PLCG2 in immune signaling pathways and its implications for disease pathogenesis. Its high specificity and reliability make it a trusted tool for advancing scientific discoveries in immunology and related fields.
Product Name:
PLC gamma 2 (PLCG2) Rabbit Polyclonal Antibody
SKU:
CAB2182
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PLC gamma 2 (PLC gamma 2 (PLCG2)) (NP_002652.2).
cytoplasm, cytosol, extracellular exosome, perinuclear region of cytoplasm, plasma membrane, ruffle membrane
Calculated MW:
148kDa
Observed MW:
175kDa
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.
Purification Method:
Affinity purification
Gene ID:
5336
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PLC gamma 2 (PLC gamma 2 (PLCG2)) antibody (CAB2182) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
