PLC gamma 1 (PLCG1) Rabbit Monoclonal Antibody (CAB8899)
- SKU:
- CAB8899
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | PLC gamma 1 (PLCG1) Rabbit Monoclonal Antibody |
SKU: | CAB8899 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 710-832 of human PLC gamma 1 (PLC gamma 1 (PLCG1)) (P19174). |
Sequence: | GKIK HCRV QQEG QTVM LGNS EFDS LVDL ISYY EKHP LYRK MKLR YPIN EEAL EKIG TAEP DYGA LYEG RNPG FYVE ANPM PTFK CAVK ALFD YKAQ REDE LTFI KSAI IQNV EKQE GGWW RGD |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1; PLC gamma 1 (PLCG1) |
Positive Sample: | HeLa,PC-12,NIH/3T3,Mouse lung,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell projection, lamellipodium, ruffle. |
Calculated MW: | 149kDa |
Observed MW: | 150kDa |
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5335 |
Clone Number: | ARC1345 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |