PLC gamma 1 (PLCG1) Rabbit Polyclonal Antibody (CAB7711)
- SKU:
- CAB7711
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | PLC gamma 1 (PLCG1) Rabbit Polyclonal Antibody |
SKU: | CAB7711 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human PLC gamma 1 (PLCG1) (NP_002651.2). |
Sequence: | NSYA ISFR AEGK IKHC RVQQ EGQT VMLG NSEF DSLV DLIS YYEK HPLY RKMK LRYP INEE ALEK IGTA EPDY GALY EGRN PGFY VEAN PMPT FKCA VKAL F |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1; PLC gamma 1 (PLCG1) |
Positive Sample: | MCF7,Jurkat,HepG2,Mouse brain,Mouse lung,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell projection, lamellipodium, ruffle. |
Calculated MW: | 149kDa |
Observed MW: | 160kDa |
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5335 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |