The PLCD1 Polyclonal Antibody (PACO49878) is a valuable tool for researchers studying Phospholipase C Delta 1 (PLCD1), an enzyme involved in cell signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blotting and immunohistochemistry applications. By targeting the PLCD1 protein, this antibody enables researchers to detect and analyze the expression of PLCD1 in various cell types, making it an ideal choice for investigations in cell biology and signal transduction research.
PLCD1 is known to play a crucial role in the regulation of cell growth, differentiation, and apoptosis, making it a key player in various physiological and pathological processes. Dysregulation of PLCD1 has been implicated in diseases such as cancer, cardiovascular disorders, and neurological conditions, highlighting its potential as a therapeutic target. By studying the function of PLCD1, researchers can gain insights into the mechanisms underlying these diseases and identify novel treatment strategies.
Antibody Name:
PLCD1 Antibody (PACO49878)
Antibody SKU:
PACO49878
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 protein (419-653AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO49878 at dilution of 1:100.
Background:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.
PLCD1: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. Defects in PLCD1 are the cause of nail disorder non- syndromic congenital type 3 (NDNC3). NDNC3 is a nail disorder characterized by a white appearance of the nail plate (true leukonychia), the nail bed (pseudoleukonychia), or neither (apparent leukonychia). Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata). 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate; PhospholipaseChromosomal Location of Human Ortholog: 3p22-p21.3Cellular Component: cytoplasm; plasma membrane; cytosolMolecular Function: signal transducer activity; phosphatidylserine binding; GTPase activating protein binding; calcium ion binding; phosphoinositide phospholipase C activityBiological Process: inositol phosphate metabolic process; phospholipid metabolic process; angiogenesis; lipid catabolic process; regulation of cell proliferationDisease: Nail Disorder, Nonsyndromic Congenital, 3
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
