The PLC gamma 1 (PLCG1) Polyclonal Antibody is a valuable tool for researchers studying the PLC gamma 1 protein, which plays a key role in intracellular signaling pathways. This antibody, produced using rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications, allowing for the detection and analysis of PLC gamma 1 expression in a variety of cell types.PLC gamma 1 is a critical enzyme involved in the regulation of cell growth, differentiation, and immune responses. Dysregulation of PLC gamma 1 has been implicated in a number of diseases, including cancer, autoimmune disorders, and neurological conditions.
By studying the activity of PLC gamma 1, researchers can gain valuable insights into the molecular mechanisms underlying these diseases and identify potential targets for therapeutic interventions.This PLC gamma 1 Polyclonal Antibody is an essential tool for researchers interested in investigating the role of PLC gamma 1 in health and disease. Its high specificity and sensitivity make it ideal for studies in cell biology, pharmacology, and immunology, providing valuable information that can help advance our understanding of disease mechanisms and inform the development of novel treatments.
Product Name:
PLC gamma 1 (PLCG1) Polyclonal Antibody
SKU:
CAB21545
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1202-1291 of human PLC gamma 1 (PLCG1) (NP_002651.2).
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5335
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PLC gamma 1 (PLCG1) Rabbit pAb (CAB21545) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
