The PLB1 Polyclonal Antibody (CAB10429) is a valuable tool for researchers studying the PLB1 protein, which plays a key role in cell membrane integrity and lipid metabolism. This antibody, produced in rabbits, is highly specific to human samples and has been extensively validated for use in Western blot applications.PLB1 is a phospholipase enzyme that is involved in lipid signaling pathways and cellular membrane structure. Its function is essential for maintaining cell viability and proper cellular function.
Studies have shown that dysregulation of PLB1 can lead to various diseases, including cancer and metabolic disorders.By using the PLB1 Polyclonal Antibody, researchers can detect and analyze PLB1 expression levels in different cell types, allowing for a better understanding of its role in various biological processes. This antibody is a valuable tool for research in lipid metabolism, cell biology, and disease mechanisms associated with PLB1 dysregulation.
Product Name:
PLB1 Rabbit Polyclonal Antibody
SKU:
CAB10429
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1110-1415 of human PLB1 (NP_694566.4).
Apical cell membrane, Single-pass type I membrane protein.
Calculated MW:
163kDa
Observed MW:
170kDa
This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene.
Purification Method:
Affinity purification
Gene ID:
151056
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PLB1 antibody (CAB10429) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
