The Plaur Polyclonal Antibody (CAB1397) is a valuable tool for researchers studying PLAU receptor (PLAUR), a cell surface molecule associated with key biological processes like cell migration, tissue remodeling, and inflammation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for various experimental applications such as Western blotting.PLAUR, also known as urokinase plasminogen activator receptor, is involved in mediating cell signaling pathways that regulate cell adhesion, migration, and invasion in cancer progression. Its overexpression is associated with poor prognosis in cancer patients, making it a potential therapeutic target in oncology research.
By targeting PLAUR, researchers can gain insights into the molecular mechanisms underlying tumor metastasis and explore novel strategies for cancer treatment.Furthermore, the Plaur Polyclonal Antibody (CAB1397) can be utilized in immunohistochemistry, flow cytometry, and other experimental techniques to investigate the expression and localization of PLAUR in various cell types and tissues. Its versatility and reliability make it an essential tool for advancing research in cancer biology, inflammation, and other fields where PLAUR plays a crucial role.
Product Name:
PLAUR Rabbit Polyclonal Antibody
SKU:
CAB1397
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-305 of human PLAUR (NP_002650.1).
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
Purification Method:
Affinity purification
Gene ID:
5329
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PLAUR antibody (CAB1397) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
