Plaur Antibody (PACO28986)
- SKU:
- PACO28986
- Product Type:
- Antibody
- Reactivity:
- Rat
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Plaur Antibody (PACO28986)
The PLaur Antibody (PAC028986) is a highly specific monoclonal antibody designed for research involving PLaur, a critical protein involved in tumor invasion and metastasis. This antibody, produced in mice, exhibits strong reactivity with human samples and has been validated for use in various applications, including immunohistochemistry and flow cytometry. By targeting the PLaur protein, this antibody enables researchers to study the role of PLaur in cancer progression and its potential as a therapeutic target.
PLaur, also known as urokinase plasminogen activator receptor (uPAR), is a key player in the plasminogen activation system and is crucial for tumor cell migration and invasion. Its overexpression is associated with poor prognosis in various cancers, making it a promising target for cancer therapy. By understanding the function of PLaur in tumor progression, researchers can develop targeted therapies to inhibit its activity and potentially prevent metastasis in cancer patients.
| Antibody Name: | Plaur Antibody (PACO28986) |
| Antibody SKU: | PACO28986 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Rat, Human |
| Immunogen: | Recombinant Rat Urokinase plasminogen activator surface receptor ptotein (25-299AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Plaur antibody at 2µg/ml Lane 1: 293T whole cell lysate Lane 2: Rat brain tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 36, 25 kDa Observed band size: 36 kDa . |
| Background: | Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. |
| Synonyms: | Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (CD_antigen: CD87), Plaur |
| UniProt Protein Function: | uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Motility/polarity/chemotaxis; Receptor, misc. Chromosomal Location of Human Ortholog: 1q21 Cellular Component: cell surface; extracellular region; focal adhesion; integral component of plasma membrane; plasma membrane Molecular Function:enzyme binding; protein domain specific binding; receptor binding; U-plasminogen activator receptor activity Biological Process: mesenchymal cell differentiation; negative regulation of apoptosis; positive regulation of DNA binding; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of protein phosphorylation; regulation of proteolysis; skeletal muscle tissue regeneration; spermatogenesis |
| NCBI Summary: | receptor for urokinase-plasminogen activator; may play a central role in malignant tumour progression [RGD, Feb 2006] |
| UniProt Code: | P49616 |
| NCBI GenInfo Identifier: | 8394516 |
| NCBI Gene ID: | 50692 |
| NCBI Accession: | NP_059046.1 |
| UniProt Secondary Accession: | P49616,O35771, P51573, Q7TN35, |
| UniProt Related Accession: | P49616 |
| Molecular Weight: | 24,417 Da |
| NCBI Full Name: | urokinase plasminogen activator surface receptor isoform 2 |
| NCBI Synonym Full Names: | plasminogen activator, urokinase receptor |
| NCBI Official Symbol: | Plaur  |
| NCBI Official Synonym Symbols: | Par; uPAR; Plaur3; uPAR-2; uPAR-3Â Â |
| NCBI Protein Information: | urokinase plasminogen activator surface receptor |
| UniProt Protein Name: | Urokinase plasminogen activator surface receptor |
| UniProt Synonym Protein Names: | CD_antigen: CD87 |
| UniProt Gene Name: | Plaur  |
| ELISA Kits |
| Rat uPAR ELISA Kit |
| Rat PLAUR/uPAR (Plasminogen Activator, Urokinase Receptor) CLIA Kit (RTES00586) |
| Rat Urokinase plasminogen activator surface receptor (Plaur) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
PLAUR Rabbit Polyclonal Antibody (CAB1397)
Mouse PLAUR / uPAR ELISA Kit
Human PLAUR/uPAR (Plasminogen Activator, Urokinase Receptor) ELISA Kit (HUES02608)
Human Urokinase plasminogen activator surface receptor (PLAUR) ELISA Kit (HUEB0161)
