The PLAU Polyclonal Antibody (CAB2181) is a valuable tool for researchers studying the PLAU gene, which encodes urokinase plasminogen activator (uPA), a protease involved in various physiological and pathological processes, including cell migration and tissue remodeling. This antibody, generated in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.The PLAU Polyclonal Antibody specifically binds to the PLAU protein, allowing for the detection and analysis of uPA expression in a variety of cell types. This makes it an ideal choice for studies in the fields of cancer research, cardiovascular diseases, and inflammation.
By targeting uPA, researchers can gain insights into the role of this protease in disease progression and potentially identify new therapeutic targets.Overall, the PLAU Polyclonal Antibody is a reliable tool for investigating the functions of urokinase plasminogen activator and its implications in various disease states. Its high specificity and sensitivity make it a valuable asset for researchers aiming to elucidate the molecular mechanisms underlying PLAU gene function.
Product Name:
PLAU Rabbit Polyclonal Antibody
SKU:
CAB2181
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-180 of human PLAU (NP_002649.1).
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
5328
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PLAU Rabbit pAb (CAB2181) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
