The Plat Rabbit Monoclonal Antibody (CAB4210) is a cutting-edge tool for researchers studying CD300A, a cell surface molecule with important implications in immune regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. Through binding to the CD300A protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an indispensable resource for investigations in immunology and cancer research.CD300A, also known as an immune inhibitory receptor, plays a crucial role in maintaining immune homeostasis by modulating inflammation and suppressing allergic reactions.
Its pivotal role in regulating immune responses underscores its relevance as a target for research into conditions such as cancer, autoimmune diseases, and chronic inflammatory disorders. Unlocking the mechanisms of CD300A activity is essential for the development of therapies that effectively modulate or harness immune function in the treatment of these complex conditions.
Product Name:
tPA/PLAT Rabbit Monoclonal Antibody
SKU:
CAB4210
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 463-562 of human tPA/tPA/PLAT (P00750).
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
5327
Clone Number:
ARC0928
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using tPA/tPA/PLAT Rabbit mAb (CAB4210) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
