tPA/PLAT Rabbit Polyclonal Antibody (CAB5655)
- SKU:
- CAB5655
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
Product Name: | tPA/PLAT Rabbit Polyclonal Antibody |
SKU: | CAB5655 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-320 of human tPA/tPA/PLAT (NP_000921.1). |
Sequence: | SQEI HARF RRGA RSYQ VICR DEKT QMIY QQHQ SWLR PVLR SNRV EYCW CNSG RAQC HSVP VKSC SEPR CFNG GTCQ QALY FSDF VCQC PEGF AGKC CEID TRAT CYED QGIS YRGT WSTA ESGA ECTN WNSS ALAQ KPYS GRRP DAIR LGLG NHNY CRNP DRDS KPWC YVFK AGKY SSEF CSTP ACSE GNSD CYFG NGSA YRGT HSLT ESGA SCLP WNSM ILIG KVYT AQNP SAQA LGLG KHNY CRNP DGDA KPWC HVLK NRRL TWEY CDVP SCST CGLR QYSQ PQFR IKGG LFAD IA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | TPA; T-PA; tPA/PLAT |
Positive Sample: | NCI-H460 |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular space. |
Calculated MW: | 63kDa |
Observed MW: | 63kDa |
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Purification Method: | Affinity purification |
Gene ID: | 5327 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |