The Plastin-3 Polyclonal Antibody (CAB3627) is a valuable tool for researchers studying Plastin-3, a protein involved in actin bundling and cytoskeletal organization. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the Plastin-3 protein, researchers can accurately detect and analyze its expression in various cell types.Plastin-3 plays a crucial role in cell motility, adhesion, and migration, making it a key player in processes such as development, tissue repair, and cancer metastasis. Its involvement in cytoskeletal dynamics and cell signaling pathways makes it an intriguing target for investigations in cell biology and cancer research.
By understanding the function and regulation of Plastin-3, researchers can gain insight into its contribution to normal cellular processes and disease pathology.The Plastin-3 Polyclonal Antibody is a valuable tool for studying the roles of Plastin-3 in various cellular processes and disease conditions. Its high specificity and sensitivity make it an ideal choice for researchers interested in unraveling the complexities of Plastin-3 biology and its implications in health and disease.
Product Name:
PLS3 Rabbit Polyclonal Antibody
SKU:
CAB3627
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PLS3 (NP_005023.2).
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5358
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung using PLS3 Rabbit pAb(CAB3627) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
