The Plastin 2 Polyclonal Antibody (CAB5561) is a valuable tool for researchers studying Plastin 2, a protein involved in actin cytoskeleton organization and cell migration. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the Plastin 2 protein, allowing for detection and analysis in a variety of cell types.Plastin 2 plays a crucial role in cell motility and invasion, making it an important target for research in cancer metastasis and other cellular processes.
By understanding the function and regulation of Plastin 2, researchers can gain insights into the mechanisms underlying these processes and develop potential therapeutic strategies for cancer and other diseases. This antibody is a valuable tool for investigating the role of Plastin 2 in various biological processes and diseases.
Product Name:
LCP1 Rabbit Polyclonal Antibody
SKU:
CAB5561
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human L-Plastin/LCP1 (NP_002289.2).
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.
Purification Method:
Affinity purification
Gene ID:
3936
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using L-Plastin/LCP1 Rabbit pAb (CAB5561) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
