PLAGL1 Antibody (PACO22735)
- SKU:
- PACO22735
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PLAGL1 Antibody (PACO22735)
The Plagl1 Polyclonal Antibody (PACO22735) is a versatile tool for researchers studying the role of Pleomorphic Adenoma Gene-Like 1 (Plagl1) in various biological processes. Plagl1 is a transcription factor that has been implicated in cell proliferation, apoptosis, and differentiation, particularly in the context of cancer development and progression.This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the Plagl1 protein, researchers can accurately detect and analyze its expression in different cell types and tissues, making it an ideal choice for studies in cancer biology, developmental biology, and stem cell research.
Plagl1 is known to play a critical role in regulating key cellular processes, making it a potential target for therapeutic intervention in cancer and other diseases. Understanding the function of Plagl1 and its downstream targets can provide valuable insights into the molecular mechanisms underlying disease pathogenesis, paving the way for the development of targeted therapies and personalized treatment strategies.
| Antibody Name: | PLAGL1 Antibody (PACO22735) |
| Antibody SKU: | PACO22735 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human PLAGL1. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from 293 cells, using PLAGL1 antibody. |
| Background: | Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide. |
| Synonyms: | Zinc finger protein PLAGL1; Pleiomorphic adenoma-like protein 1; Tumor supressor ZAC; Lost on transformation 1; LOT-1 |
| UniProt Protein Function: | PLAGL1: Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 6q24-q25 Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm; nucleus Molecular Function:DNA binding Biological Process: apoptosis; cell cycle arrest; cell differentiation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; positive regulation of transcription from RNA polymerase II promoter Disease: Diabetes Mellitus, Transient Neonatal, 1 |
| NCBI Summary: | This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015] |
| UniProt Code: | Q9UM63 |
| NCBI GenInfo Identifier: | 158523334 |
| NCBI Gene ID: | 5325 |
| NCBI Accession: | Q9UM63.2 |
| UniProt Secondary Accession: | Q9UM63,O76019, Q7Z3V8, Q92981, Q96JR9, Q9UIZ0, B2RBA4 B2RCM8, E1P595, E1P597, |
| UniProt Related Accession: | Q9UM63 |
| Molecular Weight: | 44,668 Da |
| NCBI Full Name: | Zinc finger protein PLAGL1 |
| NCBI Synonym Full Names: | PLAG1 like zinc finger 1 |
| NCBI Official Symbol: | PLAGL1Â Â |
| NCBI Official Synonym Symbols: | ZAC; LOT1; ZAC1Â Â |
| NCBI Protein Information: | zinc finger protein PLAGL1 |
| UniProt Protein Name: | Zinc finger protein PLAGL1 |
| UniProt Synonym Protein Names: | Lost on transformation 1; LOT-1; Pleiomorphic adenoma-like protein 1; Tumor suppressor ZAC |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | PLAGL1Â Â |
| UniProt Entry Name: | PLAL1_HUMAN |
| Antibodies |
| PLAGL1 Antibody (PACO01713) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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